Sedating or activating ssri, selective serotonin reuptake inhibitors (ssris)
This effect lesses as one reaches higher doses i. Parnate Tranylcypromine is extremely activating for some people, not at all a sedating medication. This is not from forum as far as I know or at least easily collated in one post, but I didn't search either.
A meta-analysis of drug company data found no evidence that SSRIs increased the risk of suicide; however, important protective or hazardous effects could not be excluded. Dry mouth Citalopram and paroxetine are more likely to cause dry mouth than escitalopram and fluoxetine.
These syndromes are short-lived, but insufficient long-term data is available to determine whether there are long-term effects. Recently, sertraline has been shown to cause statistically significantly more diarrhea than other SSRIs 7.
The possible slower onset of antidepressant action of fluoxetine may be owing to a longer time taken to achieve therapeutic plasma concentrations. Abrupt interruption of antidepressant therapy for days was associated with the emergence of new somatic and psychological symptoms in patients treated with paroxetine and to a lesser degree sertraline, with few symptoms seen with fluoxetine Ask in the non-SSRI forum.
The potency of the SSRIs as inhibitors of the metabolism of the PP2-D6 varies and is reported in descending order of potency as paroxetine, fluoxetine, sertraline, citalopram, and fluvoxamine. Initial treatment with fluoxetine or paroxetine may not be preferred for patients in whom a potential for a clinically significant drug-drug interaction exists.
These effects may be particularly difficult to tolerate for elderly or concomitantly medically ill patients. The long half-life of fluoxetine may blunt the effects of missed doses or treatment discontinuation and makes it easier to discontinue than any of the other SSRIs.
What does it mean " Prozac (fluoxetine) is activating" compared to other ssri?
This combination may lead to the development of a hyperserotonergic syndrome consisting of excitement, diaphoresis, rigidity, hyperthermia, tachycardia, hypertension, and possibly death. Family history of obesity genetic factors Lower levels of educational attainment Low body mass index at the beginning of antidepressant therapy Effects on sleep SSRIs interfere with sleep architecture.
Of the SSRIs, paroxetine may be responsible for the highest risk of weight gain 9. Predictors for antidepressant-induced weight gain
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